What’s the matter?
意思是你怎么了?
例句：
Why are you crying? What’s the matter?你哭什么?出什么事了?
You are acting strangely. What’s the matter with you?你最近怎么行为怪怪的，出什么事了吗?
其它同意的句子：
What’s got into you?
What’s going on?